Los Angeles, CA
Our laboratory is interested in applying synthetic biology expertise to the engineering of novel biological circuits with direct applications in health and medicine. Our focus is on mammalian systems, particularly in cell-based therapy for cancer. Current projects include rewiring cytokine-signaling pathways in T cells that can recognize the tumor microenvironment and, in response to tumor detection, simultaneously execute tumor-killing functions and recruit supporting immune responders to the tumor site. These novel systems aim to enhance the safety and efficacy of cell-based therapy to tackle currently incurable diseases.